Archive for November, 2016

November Progress

By • Nov 30th, 2016 • Category: Honors Thesis, Research

This month, I repeated my assay of toxin and biofilm interactions on four different types of media, using both K2 and K28 toxin-producing strains and two different biofilm-forming strains. I successfully took light and fluorescent images of all the pure and mixed colonies from my assay, and am now processing the colonies in order to…
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New applications and organic synthesis

By • Nov 30th, 2016 • Category: Honors Thesis, Research

I have been doing a lot of research lately into the pathophysiology of ALS, and have become interested in some of the biochemical pathways that involve some unusual and interesting chemistry. There is a wealth of information on some of the important proteins, including Superoxide Dismutase (SOD1), which is a major cause of damage when…
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Belated October Updates: Recruitment, Writing, and Applying (Cont.)

By • Nov 29th, 2016 • Category: Honors Thesis, Research

Hi there! Apologies for the belated nature of this post–it has been an insanely busy past few weeks! These updates pertain to the thesis progress made during the month of October: Recruitment-wise, we were/are still working hard to facilitate the participation of 5-10 more families. We officially passed our 80% milestone benchmark, as we had followed up with just short…
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W&M Honors Fellows 2016-11-21 16:43:36

By • Nov 21st, 2016 • Category: Honors Thesis, Research

A lot has happened these few weeks, and I’m excited to move forward with these last sessions of lab for the semester. Last time, I talked about oxidizing pyruvate kinase with DTNB – a cysteine-specific reagent. We’ve oxidized PK with HOCl and seen an inhibition of activity, but we don’t know what exactly is getting…
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The Complexities

By • Nov 19th, 2016 • Category: Honors Thesis, Research

Something that has dawned on me in the writing process is the difficulty of capturing reality. What makes history magical and captivating is in part its reliance on perspective and context and the way moments become more and more whole as more perspectives and contexts come together. As a result, history is a really, really tricky…
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Society for Neuroscience Meeting 2016

By • Nov 15th, 2016 • Category: Honors Thesis, Research

I spent this week attending the annual Society for Neuroscience (SfN) meeting 2016 in San Diego, CA. On Sunday, I presented data from a project started in my junior year. I was looking forward to this trip for a number of reasons: I would have the chance to meet many other scientists from the respiratory…
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Experimental Phase of “The Curious Case of OipA”

By • Nov 14th, 2016 • Category: Honors Thesis, Research

Hello and welcome to the wrap up of the Fall 2016 edition of “The Curious Case of OipA!” Since I was last on the SuRGe blog, I have completed phase 1 of my project, and have successfully created all of my mutant oipA strains of Helicobacter pylori. Now I am well into the experimental phase, […]

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A New Experiment!

By • Nov 14th, 2016 • Category: Honors Thesis, Research

(Potentially) exciting development in “The Curious Case of OipA”! As I was reviewing my data last week and thinking about the story of OipA and how it relates to the Cag Pathogenicity Island, I realized that I was missing a key element in this narrative. For some reason it had never occurred to me that if…
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Quick paper update: October

By • Nov 13th, 2016 • Category: Honors Thesis, Research

My post never went through for October, but I wanted to make sure everyone knows we are in the final stage of submitting our nucleophagy paper, which means another step towards integrating ALS into our research. We have had to do a number of experiments at the last minute to confirm that our techniques have been correct…
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Flex that Steric Bulk

By • Nov 9th, 2016 • Category: Honors Thesis, Research

I have data! By that I mean, I’ve finished titrations on all of my di-ortho compounds and have their average pKa values. Excel and I have become well acquainted with each other for the past couple weeks as I analyzed my data. Since we have determined that both sterics and electronics play a role in…
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